Monoclonal gammopathies
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چکیده
منابع مشابه
Monoclonal gammopathies
Clinical background The finding of a monoclonal immunoglobulin in the serum defines the so-called monoclonal gammopathy. Monoclonal components are homogeneus immunoglobulins whole (intact) or fragmented, produced by a single expanded plasma cell clone. MCs present unique physicochemical homogeneity, which is reflected in their immunological homogeinity. Immunological homogeinity by electrophore...
متن کاملThe monoclonal gammopathies.
Each monoclonal protein (M-protein, or myeloma protein) consists of two heavy polypeptide chains of the same class and subclass and two light polypeptide chains of the same type. Electrophoresis on cellulose acetate membranes is satisfactory for screening, although agarose electrophoresis is more sensitive for detecting small M-proteins. Immunoelectrophoresis should be performed when myeloma, m...
متن کاملAnkylosing spondylitis and monoclonal gammopathies.
From 1960 to 1990, 557 patients with ankylosing spondylitis (428 men, 129 women) were diagnosed and indexed in the department of rheumatology. Monoclonal gammopathies were found in seven (five men, two women) patients (1.3%). With one exception, ankylosing spondylitis preceded monoclonal gammopathies by many years. The distribution of the isotypes of the mIg found in these seven patients was st...
متن کاملScreening algorithms for monoclonal gammopathies.
In this issue of Clinical Chemistry, Piehler et al. (1 ) present data on the use of serum protein electrophoresis (SPE), clinical history, and selective use of serum immunoglobulin free light chain (FLC) assay as a diagnostic screening algorithm for multiple myeloma (MM) in a general hospital population and conclude that this algorithm allows for efficient diagnosis or exclusion of multiple mye...
متن کاملAL-amyloidosis in monoclonal gammopathies.
Sixty-two patients affected by MGUS underwent fat tissue aspirate examination for diagnosis of AL amyloidosis. Nine out of the 62 were found to be Congo red positive. MGUS had already been diagnosed for quite a long time in about 60% of these patients, while this prevalence decreased to 24% among the Congo red negative patients. The follow-up of the positive patients is reported.
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ژورنال
عنوان ژورنال: BMC Geriatrics
سال: 2010
ISSN: 1471-2318
DOI: 10.1186/1471-2318-10-s1-l73